Preventing cognitive decline in healthy older adults
نویسندگان
چکیده
منابع مشابه
Predicting cognitive decline in healthy older adults.
OBJECTIVE Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. METHODS A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer...
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Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders. This prospective study evaluated individual and combined contributions of demographic information, genetic risk, hippocampal volume, and fMRI activation for predicting cognitive decline after an 18-month retes...
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CONTEXT The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning. OBJECTIVE To determine whether G. biloba slows the rates of global or domain-specific cognitive decline in older adults. DESIGN, SETTING, AND PARTI...
متن کاملStronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults.
OBJECTIVE Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear. METHODS Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part o...
متن کاملCorrelation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults.
BACKGROUND Abnormal cerebrospinal fluid (CSF) biomarker levels predict development of Alzheimer disease with good accuracy and are thought to precede cognitive deterioration. OBJECTIVE To investigate whether changes in CSF biomarker levels over time in healthy older adults are associated with a concurrent decline in cognitive performance. DESIGN Retrospective analysis of longitudinal CSF bi...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2013
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.121448